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Recovery of Unrelated Donors of Peripheral Blood Stem Cells versus Recovery of Unrelated Donors of Bone Marrow: A Prespecified Analysis from the Phase.

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Presentation on theme: "Recovery of Unrelated Donors of Peripheral Blood Stem Cells versus Recovery of Unrelated Donors of Bone Marrow: A Prespecified Analysis from the Phase."— Presentation transcript:

1 Recovery of Unrelated Donors of Peripheral Blood Stem Cells versus Recovery of Unrelated Donors of Bone Marrow: A Prespecified Analysis from the Phase III Blood and Marrow Transplant Clinical Trials Network Protocol 0201  Linda J. Burns, Brent R. Logan, Pintip Chitphakdithai, John P. Miller, Rebecca Drexler, Stephen Spellman, Galen E. Switzer, John R. Wingard, Claudio Anasetti, Dennis L. Confer  Biology of Blood and Marrow Transplantation  Volume 22, Issue 6, Pages (June 2016) DOI: /j.bbmt Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Probability of complete recovery by donation of peripheral blood stem cells (PBSC) or bone marrow (BM). (A) All donors, (B) All donors, (C) All donors, (D) Domestic donors, (E) Domestic donors, (F) Domestic donors, Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Skeletal pain and body symptoms by donation of peripheral blood stem cells (PBSC) or bone marrow. (A) Skeletal pain experienced by all donors by product at baseline and after donation. (B) Skeletal pain of domestic donors by product at baseline, peri-collection, and after donation. (C) Highest toxicity level across all body symptoms experienced by all donors by product at baseline and after donation. (D) Highest toxicity level across all body symptoms by domestic donors by product at baseline, peri-collection, and after donation. (E) Fatigue of all donors product at baseline and after donation. (F) Fatigue by domestic donors by product at baseline, peri-collection, and after donation. Peri-collection time points are day 5 of filgrastim administration for PBSC donors and day 2 after BM collection. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Box and whiskers plots of (A) white blood cell (WBC) counts, (B) neutrophil counts, (C) mononuclear cell counts, (D) hemoglobin, and (E) platelet counts, by randomized product of peripheral blood stem cells (PBSC) or bone marrow, showing the maximum, upper quartile, median, lower quartile, and minimum values at baseline and the indicated time after donation: day of collection, 1 and 6 months, and 1 and 2 years. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2016 The American Society for Blood and Marrow Transplantation Terms and Conditions


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