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A new mouse model of pancreatic cancer: PTEN gets its Akt together

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Presentation on theme: "A new mouse model of pancreatic cancer: PTEN gets its Akt together"— Presentation transcript:

1 A new mouse model of pancreatic cancer: PTEN gets its Akt together
Anirban Maitra, Ralph H. Hruban  Cancer Cell  Volume 8, Issue 3, Pages (September 2005) DOI: /j.ccr Copyright © 2005 Elsevier Inc. Terms and Conditions

2 Figure 1 Model for Pten deletion and ductal metaplasia
Pten-deficient centroacinar cells (green ovals) begin to proliferate during development. Centroacinar cell expansion leads to apoptosis of acinar cells (white triangles) due to loss of acinar integrity or survival signals. Progeny of these centroacinar cells form tubular complexes with mucinous metaplasia. Reproduced with permission from Stanger et al. (2005). Cancer Cell 2005 8, DOI: ( /j.ccr ) Copyright © 2005 Elsevier Inc. Terms and Conditions

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