1. Trends over time in Escherichia coli bloodstream infections, urinary tract infections, and antibiotic susceptibilities in Oxfordshire, UK, 1998–2016: a study of electronic health records 
Karina-Doris Vihta, MMath, Nicole Stoesser, DPhil, Prof Martin J Llewelyn, PhD, T Phuong Quan, MSc, Tim Davies, MBBS, Nicola J Fawcett, BMBCh, Laura Dunn, MSc, Katie Jeffery, BMBCh, Prof Chris C Butler, FMedSci, Gail Hayward, DPhil, Monique Andersson, MD, Marcus Morgan, MSc, Sarah Oakley, MSc, Amy Mason, PhD, Susan Hopkins, FRCP, David H Wyllie, PhD, Prof Derrick W Crook, MBBCh, Prof Mark H Wilcox, MD, Prof Alan P Johnson, PhD, Prof Tim E A Peto, FRCP, Prof A Sarah Walker, PhD 
The Lancet Infectious Diseases 
Volume 18, Issue 10, Pages (October 2018)
DOI: /S (18)
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2. Figure 1
Monthly Escherichia coli bloodstream infection (A) and UTI (B) including both first and recurrent infections, by time since hospital exposure, 1998–2016
Only counting E coli bloodstream infection recurrences occurring more than 14 days after an index positive culture, and E coli UTI recurrences more than 90 days after an index positive culture. In panel B, quasi-nosocomial and nosocomial data are plotted from 0 to 250 cases because fewer cases were recorded in these populations. The line through the datapoints is the estimated incidence by iterative sequential regression (ISR). The lines at the base of the graph are 95% CIs around the breakpoints estimated by the ISR model. IRR is estimated for IRR=incidence rate ratio. UTI=urinary tract infection.
The Lancet Infectious Diseases  , DOI: ( /S (18) )
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3. Figure 2
Estimated relative change in incidence for Escherichia coli bloodstream infections (A), E coli UTIs (B), and severity of co-amoxiclav-resistant and co-amoxiclav-susceptible E coli bloodstream infections (C)
IRR points are estimated for 2016, with 95% CI as error bars. Severity of infection is measured by use of 30-day mortality and concentration of C-reactive protein and given as RR. Previous UTI means a UTI 3 days or more previously. Numbers and heterogeneity tests are in the appendix (p 9). IRR=incidence rate ratio. RR=rate ratio. UTI=urinary tract infection.
The Lancet Infectious Diseases  , DOI: ( /S (18) )
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4. Figure 3
Escherichia coli bloodstream infection according to time since hospital exposure and urinary tract infection contribution, 1998–2016
(A) Annual proportion of samples submitted. (B) Number of cultures submitted per year, definitions in appendix (p 3).
The Lancet Infectious Diseases  , DOI: ( /S (18) )
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5. Figure 4
Annual number of Escherichia coli bloodstream infections susceptible (A) and resistant (B) to co-amoxiclav, and antibiogram of susceptibility (C), by hospital-exposure group, 1998–2016
Annual IRR estimated in All co-amoxiclav susceptible IRR 1·03, 95% CI 1·02–1·04; p<0·0001; all co-amoxiclav resistant IRR 1·14, 95% CI 1·09–1·18; p<0·0001.IRR=incidence rate ratio. R=resistant. S=susceptible.
The Lancet Infectious Diseases  , DOI: ( /S (18) )
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