1. Joint instability leads to long-term alterations to knee synovium and osteoarthritis in a rabbit model 
C. Egloff, D.A. Hart, C. Hewitt, P. Vavken, V. Valderrabano, W. Herzog 
Osteoarthritis and Cartilage 
Volume 24, Issue 6, Pages (June 2016)
DOI: /j.joca
Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
Elevation of gene expression of mRNA levels in percent of controls. Collagen 1/3, Nitric oxide (iNOS), Interleukin 1β/6, and TNF-β were significantly up-regulated compared to normals and to the contralateral limb.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

3. Fig. 2
Mean histological score of the articular cartilage and synovium according to OARSI. The experimental knees showed significant higher scores compared to normals and contralaterals (*P = 0.03, respectively).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

4. Fig. 3
Synovial subanalysis according to OARSI: Experimental botox group showed significant elevation of cell proliferation and hypertrophy (P < 0.001), granulocytes (P < 0.001), lymphoplasmatic infiltrate (P < 0.001) and vascularity (P < 0.001) compared to untreated controls (marked with *). BTX-A group showed significant differences compared to the contralateral side in cell proliferation (P < 0.001), cell hypertrophy (P < 0.001), proliferation of fibroblasts (P = 0.03) and hemosiderosis (P = 0.02) (marked with **).
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

5. Fig. 4
Microscopic image of the histological analysis of synovial tissue (20× magnification): Sample of untreated control (A), OARSI Score 3; synovial sample of experimental knee (B), OARSI score 14 with cell proliferation and hypertrophy, lymphoplasmatic infiltrates and neoangiogenesis.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

6. Fig. 5
Microscopic image of the histological analysis of cartilage tissue of the tibial plateau (20× magnification): Sample of untreated control (A), OARSI Score 3; synovial sample of experimental knee (B), OARSI score 15 with erosion of cartilage, decreased chondrocyte density and increased cluster formations.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions