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How Good Roommates Can Protect against Microbial Sepsis

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Presentation on theme: "How Good Roommates Can Protect against Microbial Sepsis"— Presentation transcript:

1 How Good Roommates Can Protect against Microbial Sepsis
Rudi Beyaert, Claude Libert  Cell Host & Microbe  Volume 23, Issue 3, Pages (March 2018) DOI: /j.chom Copyright © 2018 Elsevier Inc. Terms and Conditions

2 Figure 1 Co-housing Turns Mouse from Sepsis Sensitive to Resistant
Mouse A and B are genetically identical but are bred in different animal facilities. Mouse A has a gut microbiome that is rich in diversity and that leads to high blood IgA levels and resistance to peritoneal sepsis, while mouse B is devoid of systemic IgA-mediated immunity against sepsis because of a poor diversity in microbiome. By co-housing and fecal transfer, mouse B also becomes rich in microbiome, and blood IgA increases, providing resistance to sepsis. How the microbiome leads to IgA-producing plasma cells in the bone marrow is not yet clear. Puncture of the cecum of the IgA-loaded mouse leads to bacterial leakage in the peritoneum and organs, where IgA-mediated immune responses provide protection. Cell Host & Microbe  , DOI: ( /j.chom ) Copyright © 2018 Elsevier Inc. Terms and Conditions

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