1. Singular Expression of Olfactory Receptor Genes
Ivan Rodriguez 
Cell 
Volume 155, Issue 2, Pages (October 2013)
DOI: /j.cell
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2. Figure 1 The OR-Driven Feedback Loop
Before choice, OR genes are in a silenced state, aggregated in heterochromatin foci (dark area in the nucleus) (Clowney et al., 2012). The derepression of a single OR gene involves LSD1 and a still-unknown demethylase partner (1) (Lyons et al., 2013). A positive cis-regulatory element, associated with the chosen OR gene, is shown in yellow. Translation of the OR in the endoplasmic reticulum (2) drives a UPR and activates the Perk signaling pathway (3) that leads to the phosphorylation of eIF2a (4) and the subsequent production of the nuclear isoform of ATF5 (5). ATF5 then directs the transcription of Adcy3 (6), which is required to negatively regulate LSD1 to relieve the UPR and for the neuron to mature (Dalton et al., 2013).
Cell  , DOI: ( /j.cell )
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