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Current accepted hemodynamic criteria for critical limb ischemia do not accurately stratify patients at high risk for limb loss  Raghuveer Vallabhaneni,

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Presentation on theme: "Current accepted hemodynamic criteria for critical limb ischemia do not accurately stratify patients at high risk for limb loss  Raghuveer Vallabhaneni,"— Presentation transcript:

1 Current accepted hemodynamic criteria for critical limb ischemia do not accurately stratify patients at high risk for limb loss  Raghuveer Vallabhaneni, MD, Corey A. Kalbaugh, MS, Ana Kouri, BA, Mark A. Farber, MD, William A. Marston, MD  Journal of Vascular Surgery  Volume 63, Issue 1, Pages (January 2016) DOI: /j.jvs Copyright © 2016 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Kaplan-Meier survival analysis of patients stratified by toe pressure (TP). Unadjusted hazard ratio (HR), toe hemodynamic pressure group 1 (TP, 11-30 mm Hg): 1.33; 95% confidence interval [CI], ; P = .18. Unadjusted HR, toe hemodynamic pressure group 2 (TP, 0-10 mm Hg): 1.76; 95% CI, ; P = .01∗. Adjusted HR, toe hemodynamic pressure group 1(TP, 11-30 mm Hg): 1.54; 95% CI, ; P = .06. Adjusted HR, toe hemodynamic pressure group 2: (TP, 0-10 mm Hg): 2.02; 95% CI, ; P = .001∗. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Kaplan-Meier limb salvage by revised toe hemodynamic pressure group. Unadjusted hazard ratio (HR), toe hemodynamic pressure group 1: 1.68; 95% confidence interval [CI], ; P = .18. Unadjusted HR, toe hemodynamic pressure group 2: 4.21 ; 95% CI, ; P < .0001∗. Adjusted HR, toe hemodynamic pressure group 1: 1.77; 95% CI, ; P = .15. Adjusted HR, toe hemodynamic pressure group 2: 3.70; 95% CI, ; P = .0004∗. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Kaplan-Meier amputation-free survival (AFS) by revised toe hemodynamic pressure group. Unadjusted hazard ratio (HR), toe hemodynamic pressure group 1: 1.61; 95% confidence interval [CI], ; P = .01∗. Unadjusted HR, toe hemodynamic pressure group 2: 3.20; 95% CI, ; P < .0001∗. Adjusted HR, toe hemodynamic pressure group 1: 1.66; 95% CI, ; P = .01∗. Adjusted HR, toe hemodynamic pressure group 2: 3.25; 95% CI, ; P < .0001∗. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

5 Fig 4 Kaplan-Meier survival by ankle-brachial index (ABI) value group. Unadjusted hazard ratio (HR), ABI group 1 (<0.30): 0.69; 95% confidence interval [CI], ; P = .21. Adjusted HR, ABI group 1 (<0.30): 0.76; 95% CI, ; P = .41. No significant unadjusted or adjusted HRs. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

6 Fig 5 Kaplan-Meier limb salvage by revised ankle-brachial index (ABI) value group. Unadjusted hazard ratio (HR), ABI group 1 (<0.30): 1.90; 95% confidence interval [CI], ; P = .10. Adjusted HR, ABI group 1 (<0.30): 1.99; 95% CI, ; P = .18. No significant unadjusted or adjusted HRs. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

7 Fig 6 Kaplan-Meier amputation-free survival (AFS) by revised ankle-brachial index (ABI) value group. Unadjusted hazard ratio (HR), ABI group 1 (<0.30): 1.17; 95% confidence interval [CI], ; P = .51. Adjusted HR, ABI group 1 (<0.30): 1.21; 95% CI, ; P = .48. No significant unadjusted or adjusted HRs. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

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