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Evaluation of antithymocyte globulin pharmacokinetics and pharmacodynamics in children  Naïm Bouazza, PhD, Saik Urien, MD, PhD, Bénédicte Neven, MD, Despina.

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Presentation on theme: "Evaluation of antithymocyte globulin pharmacokinetics and pharmacodynamics in children  Naïm Bouazza, PhD, Saik Urien, MD, PhD, Bénédicte Neven, MD, Despina."— Presentation transcript:

1 Evaluation of antithymocyte globulin pharmacokinetics and pharmacodynamics in children 
Naïm Bouazza, PhD, Saik Urien, MD, PhD, Bénédicte Neven, MD, Despina Moshous, MD, PhD, Jennifer Nisoy, MSc, Aurélie Gabrion, MSc, Marina Cavazzana, MD, PhD, Stéphane Blanche, MD, Jean-Marc Tréluyer, MD, PhD, Fabien Touzot, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 137, Issue 1, Pages e4 (January 2016) DOI: /j.jaci Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Concentration effect relationship of rATG.
Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 Predicted concentration time course of rATG after 3 successive doses of 4 mg/kg in patients without PLE. The shaded areas stand for the fifth and ninety-fifth percentiles of predictions. The dashed line corresponds to the threshold 1.6 μg/mL concentration. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig E1 Schema of the mechanistically based pharmacokinetic and pharmacodynamic model used for rATG concentration and lymphocyte count time course determinations. Lymphocytes are produced at a rate labeled So. These cells die at a rate labeled KTCfree and bind rATG according to the rate constant β. Antibody-lymphocyte complexes are cleared at the rate KTCbound. Antibodies are administered according to the individual dose and rate of infusion and are cleared with the elimination rate constant of rATG (KrATG). If we assume a system at steady state before initiating rATG treatment, the initial conditions of the system are as follows: rATG(0) = 0; FreeLymph(0) = So/KTCfree; and rATG-Lymph complex(0) = 0. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

5 Fig E2 Goodness-of-fit plots: observed versus population-predicted rATG concentrations and lymphocyte counts and normalized prediction distribution errors versus time for both rATG concentrations and lymphocyte counts. NPDE, Normalized prediction distribution error. Journal of Allergy and Clinical Immunology  , e4DOI: ( /j.jaci ) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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