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BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons

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Presentation on theme: "BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons"— Presentation transcript:

1 BCR-ABL1 Kinase: Hunting an Elusive Target with New Weapons
Tomasz Skorski  Chemistry & Biology  Volume 18, Issue 11, Pages (November 2011) DOI: /j.chembiol Copyright © 2011 Elsevier Ltd Terms and Conditions

2 Figure 1 Targeting the SH2-Kinase Domain Interface in BCR-ABL1
Cartoon diagram of the SH2-kinase domain interface underlining the critical role of Ile164 (I164). The 7c12 monobody interferes with the I164 to inhibit BCR-ABL1 kinase activity. Chemistry & Biology  , DOI: ( /j.chembiol ) Copyright © 2011 Elsevier Ltd Terms and Conditions

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