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Volume 18, Issue 3, Pages (June 2011)

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1 Volume 18, Issue 3, Pages 207-213 (June 2011)
Molecular origin of Na+/Li+ exchanger: Evidence against the involvement of major cloned erythrocyte transporters  Svetlana V. Koltsova, Yulia A. Trushina, Olga A. Akimova, Pavel Hamet, Sergei N. Orlov  Pathophysiology  Volume 18, Issue 3, Pages (June 2011) DOI: /j.pathophys Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

2 Fig. 1 Effect of phloretin and amiloride on the rate of Na+ influx in human, rat and rabbit erythrocytes (A) and Na+/Li+ countertransport in rabbit erythrocytes (B). Means±S.E., obtained in experiments performed in triplicate, are shown. *, ** – p<0.02 and 0.001, respectively, compared to the controls. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

3 Fig. 2 Rate of Na+,Pi cotransport (A, B) and Na+/Li+ countertransport (C) in control (A) and Li+-loaded (B, C) human, rat and rabbit erythrocytes pre-incubated for 3h in medium C (A) or in medium B containing 140mM LiCl (B, C). For complete medium compositions, see Section 2. NLCT activity in rabbit erythrocytes was taken as 100%. Means±S.E. are shown. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions

4 Fig. 3 Composite 2DE maps of proteins extracted from erythrocyte ghosts. Proteins detected in erythrocytes from humans, rats and rabbits are presented in blue; proteins detected only in humans and rabbits appear in red. Proteins whose density is least 5-fold higher in rabbits than in humans are shown by extra black rings. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2011 Elsevier Ireland Ltd Terms and Conditions


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