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Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates

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1 Metabolism, Activity, and Targeting of D- and L-2-Hydroxyglutarates
Dan Ye, Kun-Liang Guan, Yue Xiong  Trends in Cancer  Volume 4, Issue 2, Pages (February 2018) DOI: /j.trecan Copyright © 2017 The Authors Terms and Conditions

2 Figure 1 Metabolism and Targets of 2-Hydroxyglutarate (2-HG). The thick and thin arrows represent the primary and promiscuous reactions, respectively. FAD, flavin adenine dinucleotide; FADH2, reduced form of FAD; NADP, nicotinamide adenine dinucleotide phosphate; NADPH, reduced form of NADP. Additional abbreviations are listed in Table 1. Trends in Cancer 2018 4, DOI: ( /j.trecan ) Copyright © 2017 The Authors Terms and Conditions

3 Figure 2 Production of 2-Hydroxyglutarate (2-HG) by Promiscuous Enzymatic Reactions. The thick and thin arrows represent the primary and promiscuous reactions, respectively. PHDGH, phosphoglycerate dehydrogenase; 3PG, 3-phosphoglycerate; 3PHP, 3-phosphohydroxypyruvate. Additional abbreviations are listed in Figure 1. Trends in Cancer 2018 4, DOI: ( /j.trecan ) Copyright © 2017 The Authors Terms and Conditions

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