1. Normal Values of Esophageal Distensibility and Distension-Induced Contractility Measured by Functional Luminal Imaging Probe Panometry 
Dustin A. Carlson, Wenjun Kou, Zhiyue Lin, Monique Hinchcliff, Anjali Thakrar, Sophia Falmagne, Jacqueline Prescott, Emily Dorian, Peter J. Kahrilas, John E. Pandolfino 
Clinical Gastroenterology and Hepatology 
Volume 17, Issue 4, Pages e1 (March 2019)
DOI: /j.cgh
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2. Figure 1
FLIP panometry. A portion of a FLIP study is shown with diameter (color-coded) by time FLIP topography plot (bottom) and corresponding intraballoon pressure (top; red) and distension volume (top, blue). The EGJ-DI was calculated during the 60-mL fill volume within the EGJ region (dashed white box) and measured 6.7 mm2/mm Hg. In this subject, the maximum EGJ diameter (asterisk) occurred during a contraction at the 70-mL fill volume. The contraction-associated pressure amplitude (vertical black lines) were assessed during the 50-mL fill volume. Reprinted with permission from the Esophageal Center at Northwestern.
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh )
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3. Figure 2
EGJ distensibility. Values reflect medians obtained during the 60-mL fill volume for each subject. The median IRP in mm Hg and 24-hour AET for the 2 subjects at the ranges of EGJ-DI values are included. The potential for EGJ outlet obstruction is reflected by the intensity of red shading in the lower quartile, particularly below an EGJ-DI of 2.8 mm2/mm Hg (black dotted line), whereas susceptibility to gastroesophageal reflux may be predicted by patients within the upper quartile (blue). Reprinted with permission from the Esophageal Center at Northwestern.
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh )
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4. Figure 3
RACs. The frequencies (%) of RAC presence and occlusion status (ie, achieving the narrowest diameter < 6 mm) by distension volume are shown. *Either with occluding or nonoccluding contractions. †The cumulative results indicate RACs at any fill volume during the FLIP study (ie, 20–70 mL).
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh )
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5. Supplementary Figure 1
Association of FLIP panometry with HRM parameters and acid exposure. Each subject is represented by a row; subjects are listed by increasing EGJ-DI. RAC presence and occlusion status by distension volume are shown, as are the EGJ-DI from the 60-mL fill volume, HRM motility diagnoses, median IRP, and median distal contractile integral (DCI) values from the 10-supine swallows on HRM, and 24-hour AET. The correlations of EGJ-DI with median IRP, basal EGJ pressure, and AET were as follows: (P = .001), (P = .067), and (P = .49), respectively. The correlations of maximum EGJ diameter with median IRP, basal EGJ pressure, and AET were as follows: (P < .001), (P = .74), and 0.14 (P = .586). The median DCI was lower among subjects without occluding contractions at fill volumes of 40 mL or greater, or with RAC cessation (n = 5), that is, features potentially indicating a weak contractile response, median DCI of 1096 mm Hg/cm/s (median IQR, 927–2545 mm Hg/cm/s) than those not meeting these criteria: median DCI of 2340 (median IQR, 1762–4632) (P = .033).
Clinical Gastroenterology and Hepatology  , e1DOI: ( /j.cgh )
Copyright © 2019 AGA Institute Terms and Conditions