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Getting RNA and Protein in Phase

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Presentation on theme: "Getting RNA and Protein in Phase"— Presentation transcript:

1 Getting RNA and Protein in Phase
Stephanie C. Weber, Clifford P. Brangwynne  Cell  Volume 149, Issue 6, Pages (June 2012) DOI: /j.cell Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Intracellular Biomolecules Undergo Phase Transitions
(A) Nonbiological molecules can exist in different phases: gas, with few intermolecular interactions; liquid, with many transient intermolecular interactions; and solid, with stable bonds. Transitions between these phases are driven by external parameters such as temperature. (B) The nucleus and cytoplasm appear to be organized by similar phase transitions. Multivalent interaction domains and low-complexity sequences drive soluble RNA and protein molecules to transiently associate with each other, forming liquid-like granules in the cell. ATP-dependent biological activity could enable the cell to dynamically control the assembly and disassembly of these phases. Intriguingly, structural characterization suggests that the same intermolecular interactions underlying granule assembly can lead to the formation of stable amyloid aggregates seen in diseases such as Alzheimer's. Cell  , DOI: ( /j.cell ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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