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Figure 1. Chemical structures of DNA and tc-DNA

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1 Figure 1. Chemical structures of DNA and tc-DNA
Figure 1. Chemical structures of DNA and tc-DNA. Atomic numbering and the dihedral angles along the phosphate-sugar ... Figure 1. Chemical structures of DNA and tc-DNA. Atomic numbering and the dihedral angles along the phosphate-sugar backbone are indicated. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

2 Scheme 1. Base composition and numbering scheme of the three studied duplexes.
Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

3 Figure 6. Chemical structure of (A) Locked nucleic acids (LNA), (B) 2′-F-RNA and (C) Hexitol nucleic acids (HNA). Figure 6. Chemical structure of (A) Locked nucleic acids (LNA), (B) 2′-F-RNA and (C) Hexitol nucleic acids (HNA). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

4 Figure 2. The aromatic to H1′ region of the 250 ms NOESY spectrum of tc-DNA•RNA hybrid. The sequential H8/6-H1′ ... Figure 2. The aromatic to H1′ region of the 250 ms NOESY spectrum of tc-DNA•RNA hybrid. The sequential H8/6-H1′ connectivity pathways are indicated with green lines for the tc-DNA strand and yellow for the RNA strand. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

5 Figure 3. Comparison of the (A) tc-DNA•RNA, (B) tc-DNA•DNA and (C) tc- DNA•tc-DNA ensembles of the 10 lowest energy ... Figure 3. Comparison of the (A) tc-DNA•RNA, (B) tc-DNA•DNA and (C) tc- DNA•tc-DNA ensembles of the 10 lowest energy structures each. The nucleobases are shown in yellow, tc-DNA sugar-phosphate backbones are shown in blue, and DNA/RNA sugar-phosphate backbones are shown in red. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

6 Figure 4. Backbone thorsion angle and glycosidic angles of the final tc-DNA•RNA (A, B) tc-DNA•DNA (C, D) and ... Figure 4. Backbone thorsion angle and glycosidic angles of the final tc-DNA•RNA (A, B) tc-DNA•DNA (C, D) and tc-DNA•tc-DNA (E, F) compared to the corresponding values found in A- and B-DNA structures (G, H). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

7 Figure 5. Minor and major grooves of the determined structures in comparison with canonical A- and B-type duplexes. Figure 5. Minor and major grooves of the determined structures in comparison with canonical A- and B-type duplexes. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

8 Figure 7. (A) View of water bridges between O1P phosphate and O4′ sugar atoms of tc-DNA strand in the tc-DNA•RNA ... Figure 7. (A) View of water bridges between O1P phosphate and O4′ sugar atoms of tc-DNA strand in the tc-DNA•RNA duplex. (B) Space-filling, fragment of tc-DNA•RNA duplex showing close hydrophobic contacts between nucleobases methyl groups (yellow) and tc-DNA sugars (gray). Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) Published by Oxford University Press on behalf of Nucleic Acids Research.This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. Nucleic Acids Res, gkz197, The content of this slide may be subject to copyright: please see the slide notes for details.

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