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Ischemic preconditioning specifically restores complexes I and II activities of the mitochondrial respiratory chain in ischemic skeletal muscle  Fabien.

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Presentation on theme: "Ischemic preconditioning specifically restores complexes I and II activities of the mitochondrial respiratory chain in ischemic skeletal muscle  Fabien."— Presentation transcript:

1 Ischemic preconditioning specifically restores complexes I and II activities of the mitochondrial respiratory chain in ischemic skeletal muscle  Fabien Thaveau, MD, MSc, Joffrey Zoll, PhD, Olivier Rouyer, MD, Nabil Chafke, MD, PhD, Jean Georges Kretz, MD, Francois Piquard, PhD, Bernard Geny, MD, PhD  Journal of Vascular Surgery  Volume 46, Issue 3, Pages (September 2007) DOI: /j.jvs Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 A, Schematic representation of the mitochondrial respiratory chain with specific substrates and inhibitors. CI, Complex I (nicotinamide adenine dinucleotide [NADH]-coenzyme Q [CoQ] reductase); CII, complex II (succinate-CoQ reductase); CIII, complex III (CoQH2-c reductase); CIV, complex IV (cytochrome c oxidase); Cytc, cytochrome c; TMPD, N,N,N,′N′-tetramethyl-p-phenylenediamine dihydrochloride; e−, electron; H+, proton. B, Schematic oxygraph traces of permeabilized skeletal myofibers showing measurements of the respiratory chain complexes, using indicated substrates and inhibitor. Details of protocols are described in Method session. ADP, Adenosine diphosphate. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 A, Mitochondrial respiratory rate (Vmax) and B, acceptor control ratio (ACR) measured in permeabilized superficial gastrocnemius skeletal muscle after 5 hours of ischemia–reperfusion (IR) without (IR group) or with preconditioning protocol (PC group). SHAM, Nonischemic gastrocnemius muscle control. Results are expressed as means ± standard error of the mean. **P < .01 vs SHAM; §P < .05 vs IR group. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Maximal mitochondrial respiration evaluated with succinate (VS, complexes II, III, IV) measured in permeabilized superficial gastrocnemius skeletal muscle after 5 hours of ischemia–reperfusion (IR), without (IR group) or with preconditioning (P) protocol (PC group). SHAM, nonischemic gastrocnemius muscle control. Results are expressed as means ± standard error of the mean. *P < .01; vs SHAM; §P < .05 vs IR group. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Maximal mitochondrial respiration evaluated with N,N,N,′N′-tetramethyl-p-phenylenediamine dihydrochloride-ascorbate (VTMPD, complex IV) measured in permeabilized superficial gastrocnemius skeletal muscle after 5 hours of ischemia–reperfusion (IR), without (IR group) or with preconditioning (P) protocol (P group). SHAM, nonischemic gastrocnemius muscle control group. Results are expressed as means ± standard error of the mean. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2007 The Society for Vascular Surgery Terms and Conditions

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