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Vascular endothelial growth factor enhances angiotensin II-induced aneurysm formation in apolipoprotein E-deficient mice  Edward Choke, PhD, MRCS, Gillian.

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Presentation on theme: "Vascular endothelial growth factor enhances angiotensin II-induced aneurysm formation in apolipoprotein E-deficient mice  Edward Choke, PhD, MRCS, Gillian."— Presentation transcript:

1 Vascular endothelial growth factor enhances angiotensin II-induced aneurysm formation in apolipoprotein E-deficient mice  Edward Choke, PhD, MRCS, Gillian W. Cockerill, PhD, Joseph Dawson, MD, MRCS, Franklyn Howe, PhD, William R.W. Wilson, MD, MRCS, Ian M. Loftus, MD, FRCS, Matthew M. Thompson, MD, FRCS  Journal of Vascular Surgery  Volume 52, Issue 1, Pages e1 (July 2010) DOI: /j.jvs Copyright © 2010 Society for Vascular Surgery Terms and Conditions

2 Fig 1 Schematic diagram of study design. AngII, Angiotensin II; IP, intraperitoneal; VEGF, vascular endothelial growth factor. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

3 Fig 2 Left, Representative magnetic resonance image coronal section with (Right) photograph of corresponding arterial tree showing suprarenal abdominal aortic aneurysm. In each mouse, nine axial T1-weighted spin-echo cross-sectional images (green lines) were acquired with 2-mm-thick contiguous slices. To ensure reproducible positioning of axial images, the central slice (5th) was aligned at the superior pole of the left kidney. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

4 Fig 3 Angiotensin (Ang) II-induced abdominal aortic aneurysm (AAA) size was significantly increased at days 21 and 28 in apolipoprotein E–/– mice treated with vascular endothelial growth factor (VEGF) for 14 (AngII+14dVEGF) or 21 (AngII+14dVEGF) days. A, Representative macroscopic photographs of the AAA are shown with corresponding cross-sectional magnetic resonance imaging scans at day 28. The maximum diameter of the aorta is outlined by the red line. Box and whisker plots show the AAA maximum diameter at (B) day 21 and (C) day 28 and maximum cross-sectional area at (D) day 21 and (E) day 28 in saline-infused (n = 4), AngII-infused (n = 5), Ang II+14dVEGF-infused (n = 3), and AngII+21dVEGF-infused (n = 4) mice. #P < .05 vs AngII infusion; §P < .05 vs Ang II infusion; †P < .05 vs AngII infusion; ††P < .05 vs Ang II infusion; ‡P < .01 vs AngII infusion; ‡‡P < .05 vs Ang II infusion; *P < .05 vs Ang II infusion; **P < .05 vs Ang II-infusion. The horizontal line in the middle of each box indicates the median; the top and bottom borders of the box mark the 75th and 25th percentiles, respectively, and the whiskers mark the 90th and 10th percentiles. Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

5 Fig 4, online only Magnetic resonance imaging was used to compare the ex vivo aortic maximum diameter measurement with the in vivo measurements at day 28. The two measurements were highly correlated with each other (Pearson r2 = 0.88). Journal of Vascular Surgery  , e1DOI: ( /j.jvs ) Copyright © 2010 Society for Vascular Surgery Terms and Conditions

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