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W. Ruppen, L. A. Steiner, J. Drewe, L. Hauenstein, S. Brugger, M. D

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Presentation on theme: "W. Ruppen, L. A. Steiner, J. Drewe, L. Hauenstein, S. Brugger, M. D"— Presentation transcript:

1 Bupivacaine concentrations in the lumbar cerebrospinal fluid of patients during spinal anaesthesia† 
W. Ruppen, L.A. Steiner, J. Drewe, L. Hauenstein, S. Brugger, M.D. Seeberger  British Journal of Anaesthesia  Volume 102, Issue 6, Pages (June 2009) DOI: /bja/aep049 Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Kinetics of bupivacaine in CSF during spinal anaesthesia in 54 study patients. Bupivacaine concentration is given in μg ml−1. British Journal of Anaesthesia  , DOI: ( /bja/aep049) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 CSF bupivacaine concentration measured at different time points. (a) Bupivacaine concentration (μg ml−1) divided by the intrathecally administered bupivacaine dose (mg) vs time in 54 study patients. (b) Ratio of CSF bupivacaine concentration (μg ml−1) divided by the intrathecally administered bupivacaine dose (mg) and weight (kg) vs time in 54 study patients. British Journal of Anaesthesia  , DOI: ( /bja/aep049) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

4 Fig 3 Spinal block level and lumbar CSF bupivacaine concentration in women and men determined at the time of the second spinal tap. British Journal of Anaesthesia  , DOI: ( /bja/aep049) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions

5 Fig 4 Effect of change in body position within and after the first 30 min after intrathecal bupivacaine administration on spinal block level in 44 patients with position change in the intervention group vs 60 patients without position change in the control group. The number of blocked segments is indicated as medians; numbers above the columns indicate the range. British Journal of Anaesthesia  , DOI: ( /bja/aep049) Copyright © 2009 British Journal of Anaesthesia Terms and Conditions


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