1. Targeting Enteric Neuroplasticity: Diet and Bugs as New Key Factors
Roberto de Giorgio, Corrado Blandizzi 
Gastroenterology 
Volume 138, Issue 5, Pages (May 2010)
DOI: /j.gastro
Copyright © 2010 AGA Institute Terms and Conditions

2. Figure 1
Schematic representation illustrating key aspects of butyrate-induced enteric neuroplasticity in the colon. Butyrate is a short-chain fatty acid (SCFA) generated in the gut lumen by resident bacteria (ie, the gut microbiota) via saccharolytic fermentation of undigested carbohydrates. Upon absorption, butyrate is taken up by myenteric neurons through type 2 monocarboxylate transporter (MCT2), thereby leading to histone deacetylase inhibition and downstream enhancement of histone H3 lysine 9 (H3K9) acetylation via Src kinase signaling. These molecular events result in rearrangement of gene transcription evoking neurochemical coding plasticity (ie, increased proportion of cholinergic neurons in the myenteric plexus). The functional outcome of such phenotypic remodelling is an enhanced colonic propulsive motility.
Gastroenterology  , DOI: ( /j.gastro )
Copyright © 2010 AGA Institute Terms and Conditions