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Coronary Artery Bypass Grafting After Percutaneous Intervention Has Higher Early Mortality: A Meta-Analysis  Salah E. Altarabsheh, MD, Salil V. Deo, MS,

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Presentation on theme: "Coronary Artery Bypass Grafting After Percutaneous Intervention Has Higher Early Mortality: A Meta-Analysis  Salah E. Altarabsheh, MD, Salil V. Deo, MS,"— Presentation transcript:

1 Coronary Artery Bypass Grafting After Percutaneous Intervention Has Higher Early Mortality: A Meta-Analysis  Salah E. Altarabsheh, MD, Salil V. Deo, MS, MCh, Dustin Hang, BA, Osama K. Haddad, MD, Yang Hyun Cho, MD, Alan H. Markowitz, MD, Soon J. Park, MD  The Annals of Thoracic Surgery  Volume 99, Issue 6, Pages (June 2015) DOI: /j.athoracsur Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Flow chart depicting study selection for meta-analysis. From: Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009;6:e (CABG = coronary artery bypass grafting.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Pooled results demonstrating that patients undergoing pCABG had significantly better early survival than those undergoing sCABG. The forest plot is stratified according to propensity-matching studies. (pCABG = primary coronary artery bypass grafting; sCABG = stent before coronary artery bypass grafting.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Funnel plot for early mortality demonstrating lack of publication bias among included studies. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

5 Fig 4 Forest plot demonstrating individual and pooled risk ratios (RR) for postoperative myocardial infarction stratified according to propensity matching (PP). Whereas PP studies demonstrate that risk is comparable, other studies clearly favor the pCABG cohort. (CI = confidence interval; pCABG = primary coronary artery bypass grafting; sCABG = stent before coronary artery bypass grafting.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

6 Fig 5 Incidence of postoperative renal dysfunction is significantly higher after sCABG (p = 0.01). (pCABG = primary coronary artery bypass grafting; sCABG = stent before coronary artery bypass grafting.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

7 Fig 6 Pooled analysis of adjusted hazard ratios performed by inverse variance weighting, demonstrating that survival at the end of 3/5 years is comparable in both sCABG and pCABG cohorts. (CI = confidence interval; pCABG = primary coronary artery bypass grafting; sCABG = stent before coronary artery bypass grafting.) The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

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