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The Pharmacology of T Cell Therapies

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Presentation on theme: "The Pharmacology of T Cell Therapies"— Presentation transcript:

1 The Pharmacology of T Cell Therapies
Michael C. Milone, Vijay G. Bhoj  Molecular Therapy - Methods & Clinical Development  Volume 8, Pages (March 2018) DOI: /j.omtm Copyright © 2018 The Authors Terms and Conditions

2 Figure 1 Schematic Depiction of the Adoptive T Cell Immunotherapy Process for Tumor-Infiltrating Lymphocyte or Engineered T Cell Therapy Molecular Therapy - Methods & Clinical Development 2018 8, DOI: ( /j.omtm ) Copyright © 2018 The Authors Terms and Conditions

3 Figure 2 Variables Impacting Efficacy of T Cell Therapy
Many recipient and product factors are thought to impact the efficacy of adoptive T cell therapy. Although effects have largely not been tested in human trials, in vitro, preclinical in vivo, and human trial evidence implicate parameters at all points of the T cell therapy “life cycle”: (1) disease type, (2) prior therapy, (3) expansion culture conditions (e.g., cytokine and length of culture), including T cell phenotype of the product, (4) synthetic antigen receptor design, (5) pre-conditioning regimen and tumor burden, (6) T cell dose, and (7) post-infusion therapy. (8) Recipient genetics, especially those related to immunity, likely also impact efficacy. Molecular Therapy - Methods & Clinical Development 2018 8, DOI: ( /j.omtm ) Copyright © 2018 The Authors Terms and Conditions


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