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Published byLaura Goodman Modified over 5 years ago
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Reduced membranous β-catenin protein expression is associated with metastasis and poor prognosis in squamous cell carcinoma of the esophagus Po-Kuei Hsu, MD, Anna Fen-Yau Li, MD, PhD, Yi-Ching Wang, PhD, Chih-Cheng Hsieh, MD, Min-Hsiung Huang, MD, Wen-Hu Hsu, MD, Han-Shui Hsu, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 135, Issue 5, Pages (May 2008) DOI: /j.jtcvs Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions
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Figure 1 Immunohistochemical staining patterns of β-catenin in ESCC (original magnification ×400). A, Preserved β-catenin staining at the cell membrane and normal staining in the cytoplasm. B, Reduced staining at the cell membrane and increased β-catenin staining in the cytoplasm. C, Reduced β-catenin staining at the cell membrane and no staining in the cytoplasm. D, Preserved β-catenin staining at the cell membrane and increased staining in the cytoplasm. The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions
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Figure 2 The Kaplan–Meier survival curve for protein expression of membranous β-catenin, indicating that patients with reduced membranous β-catenin protein expression had a poor prognosis (log–rank test, P = .005). The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions
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Figure 3 The Kaplan–Meier survival curve for protein expression of p53 and membranous β-catenin, showing that combined increased p53 expression and reduced β-catenin expression was associated with a poor prognosis (log–rank test, P = .012). The Journal of Thoracic and Cardiovascular Surgery , DOI: ( /j.jtcvs ) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions
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