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Characterization of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach  Véronique Schulten, MSc, Astrid Radakovics,

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Presentation on theme: "Characterization of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach  Véronique Schulten, MSc, Astrid Radakovics,"— Presentation transcript:

1 Characterization of the allergic T-cell response to Pru p 3, the nonspecific lipid transfer protein in peach  Véronique Schulten, MSc, Astrid Radakovics, Christina Hartz, PhD, Adriano Mari, MD, Sonia Vazquez-Cortes, MD, Montserrat Fernandez-Rivas, MD, Iris Lauer, PhD, Beatrice Jahn-Schmid, PhD, Thomas Eiwegger, MD, Stephan Scheurer, PhD, Barbara Bohle, PhD  Journal of Allergy and Clinical Immunology  Volume 124, Issue 1, Pages (July 2009) DOI: /j.jaci Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

2 Fig 1 Lymphoproliferation of PBMCs from patients with (solid circles) and without (open circles) peach allergy to titrated concentrations of Pru p 3. SIs are shown. The symbols represent individual patients, and the horizontal lines indicate the median. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

3 Fig 2 T-cell epitopes of Pru p 3. One Pru p 3–specific TCL from each Italian (I1-I10) and Spanish (S1-S8) donor with peach allergy was stimulated with 27 overlapping peptides representing the aa sequence of the allergen. Peptides inducing SIs of greater than 2.5 are shown as gray boxes, and peptides inducing SIs of greater than 5 are shown as black boxes. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

4 Fig 3 Expression of integrin β7 on allergen-specific T cells. TCCs specific for allergens in peach (Pru p 3), peanut (Ara h 1), and pollen from timothy grass (Phl p 2), birch (Bet v 1), and mugwort (Art v 1) were stained for integrin β7. The x-axis of each histogram shows staining with anti-human integrin β7 (solid line) and the matched isotype control (dashed line) in a gate set on CD4+ cells. Journal of Allergy and Clinical Immunology  , DOI: ( /j.jaci ) Copyright © 2009 American Academy of Allergy, Asthma & Immunology Terms and Conditions

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