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Preimplantation genetic diagnosis for Duchenne muscular dystrophy by multiple displacement amplification  Zi Ren, M.D., Ph.D., Hai-tao Zeng, M.D., Ph.D.,

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Presentation on theme: "Preimplantation genetic diagnosis for Duchenne muscular dystrophy by multiple displacement amplification  Zi Ren, M.D., Ph.D., Hai-tao Zeng, M.D., Ph.D.,"— Presentation transcript:

1 Preimplantation genetic diagnosis for Duchenne muscular dystrophy by multiple displacement amplification  Zi Ren, M.D., Ph.D., Hai-tao Zeng, M.D., Ph.D., Yan-wen Xu, M.D., Ph.D., Guang-lun Zhuang, M.D., Jie Deng, M.D., Ph.D., Cheng Zhang, M.D., Ph.D., Can-quan Zhou, M.D.  Fertility and Sterility  Volume 91, Issue 2, Pages (February 2009) DOI: /j.fertnstert Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

2 Figure 1 Case 1: PGD for a female carrier with a duplication of exons 3–11 in the dystrophin gene. Arrows indicate where familial mutations are located. Npat and Nmat correspond to paternal and maternal normal dystrophin haplotype, respectively. Dup represents dystrophin duplication haplotype. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

3 Figure 2 Case 2: PGD for a female carrier with a deletion of exons 47–50. Arrows indicate where familial mutations are located. Npat and Nmat correspond to paternal and maternal normal dystrophin haplotype, respectively. Del represents dystrophin deletion haplotype. Fertility and Sterility  , DOI: ( /j.fertnstert ) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions


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