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Link between metformin and the peroxisome proliferator-activated receptor γ pathway in the uterine tissue of hyperandrogenized prepubertal mice Evelin M. Elia, Carolina Pustovrh, Ph.D., Sabrina Amalfi, Luigi Devoto, Ph.D., Alicia Beatriz Motta, Ph.D. Fertility and Sterility Volume 95, Issue 8, Pages e1 (June 2011) DOI: /j.fertnstert Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions
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(A) A representative gel corresponding to the protein of peroxisome proliferator-activated receptors type γ (PPAR γ1 and 2). (B) A representative gel corresponding to the mRNA expression of PPAR γ. The graphs correspond to the integrated optical density of bands, ∗∗∗ P< by analysis of variance. (C) A representative gel corresponding to the protein of 12 lipoxygenase (12- LOX). (D) A representative gel corresponding to the mRNA expression of 12 lipoxygenase (12- LOX). The graphs correspond to the integrated optical density of bands, ∗P< 0.05 by analysis of variance. (E) A representative gel corresponding to the protein of 15 lipoxygenase (15- LOX). (F) A representative gel corresponding to the mRNA expression of 15 lipoxygenase (15- LOX). The graphs correspond to the integrated optical density of bands, ∗∗P< 0.01 by analysis of variance. Fertility and Sterility , e1DOI: ( /j.fertnstert ) Copyright © 2011 American Society for Reproductive Medicine Terms and Conditions
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