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Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis  Daniel.

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Presentation on theme: "Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis  Daniel."— Presentation transcript:

1 Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis  Daniel D. Myers, DVM, MPH, Peter K. Henke, MD, Patricia W. Bedard, BS, Shirley K. Wrobleski, BS, Neelu Kaila, PhD, Gray Shaw, PhD, Thomas R.. Meier, DVM, Angela E. Hawley, MS, Robert G. Schaub, PhD, Thomas W. Wakefield, MD  Journal of Vascular Surgery  Volume 44, Issue 3, Pages (September 2006) DOI: /j.jvs Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

2 Fig 1 Rat inferior vena cava (IVC) stenosis model of venous thrombosis. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

3 Fig 2 Study design using the rat stenosis model of deep venous thrombosis. IVC, Inferior vena cava. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

4 Fig 3 Vein wall tensiometric analysis. LOV, Lovenox (enoxaparin); CTR, control; NORM, normal. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

5 Fig 4 Vein wall intimal thickness scoring. LOV, Lovenox (enoxaparin); CTR, control. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

6 Fig 5 A, Vein wall interleukin 13 antigen levels. LOV, Lovenox (enoxaparin); CTR, control; NORM, normal. B, Vein wall monocyte chemotactic protein 1/JE (MCP-1/JE) antigen levels. C, Vein wall platelet-derived growth factor ββ (PDGF-BB) antigen levels. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

7 Fig 6 Vein wall morphometrics. LOV, Lovenox (enoxaparin); CTR, control; TC, total inflammatory cell; MONO, monocytes; LYMPH, lymphocytes; PMN, polymorphonuclear cells; HPF, high-power field. Journal of Vascular Surgery  , DOI: ( /j.jvs ) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

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