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Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study  Dr Oriol Mitjà, MD, Camila González-Beiras, BSc,

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Presentation on theme: "Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study  Dr Oriol Mitjà, MD, Camila González-Beiras, BSc,"— Presentation transcript:

1 Effectiveness of single-dose azithromycin to treat latent yaws: a longitudinal comparative cohort study  Dr Oriol Mitjà, MD, Camila González-Beiras, BSc, Charmie Godornes, BSc, Reman Kolmau, BSc, Wendy Houinei, HEO, Haina Abel, BSc, August Kapa, BSc, Raymond Paru, BSc, Sibauk V Bieb, MaHM, James Wangi, MPH, Sergi Sanz, MSc, Kingsley Asiedu, MPH, Prof Sheila A Lukehart, PhD, Prof Quique Bassat, MD  The Lancet Global Health  Volume 5, Issue 12, Pages e1268-e1274 (December 2017) DOI: /S X(17) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

2 Figure 1 Study profile TP=Treponema pallidum subsp pertenue. TPHA=T pallidum haemagglutination assay. RPR=rapid plasma reagin. The Lancet Global Health 2017 5, e1268-e1274DOI: ( /S X(17) ) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

3 Figure 2 Serological cure or seroreversion by infection status
Serological cure (decrease in RPR titre by two or more dilutions) was determined as a function of (A) time of retesting after treatment and (B) baseline RPR titre. Seroreversion (RPR reverted to non-reactive) was determined as a function of (C) time of retesting after treatment and (D) baseline RPR titre. We report proportions of patients with latent or active yaws with serological cure at 6, 12, and 24 months. Asymptomatic participants were not followed up at 6 months and, therefore, data are included in the latent yaws group at 12 and 24 months only. RPR=rapid plasma reagin. The Lancet Global Health 2017 5, e1268-e1274DOI: ( /S X(17) ) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions


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