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Volume 154, Issue 6, Pages 1602-1619.e1 (May 2018)
Lamins and Lamin-Associated Proteins in Gastrointestinal Health and Disease Graham F. Brady, Raymond Kwan, Juliana Bragazzi Cunha, Jared S. Elenbaas, M. Bishr Omary Gastroenterology Volume 154, Issue 6, Pages e1 (May 2018) DOI: /j.gastro Copyright © 2018 AGA Institute Terms and Conditions
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Figure 1 Schematic of the nuclear envelope structure including outer and inner nuclear membranes, the lamina, integral membrane proteins, nuclear pore complex, LINC complexes, components of the cytoplasmic cytoskeleton, and chromatin-lamina contacts. The outer nuclear membrane is shown in continuity with the membrane of the endoplasmic reticulum (ER). A portion of LMNA is shown as a soluble nucleoplasmic protein, some of which is bound to LAP2α. Gastroenterology , e1DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions
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Figure 2 Affected pathways in laminopathies and potential avenues for therapeutic intervention. Alterations in multiple pathways contribute to the pathogenesis of laminopathies. Strategies tested in preclinical or clinical studies are indicated with solid arrows. Strategies to alter growth hormone signaling via JAK and STAT proteins, which is altered in mouse hepatocytes lacking LMNA but has not been tested in animal models or clinical trials, are indicated with dashed arrows. All other agents and pathways referenced in the figure have been tested, as described in the text. Gastroenterology , e1DOI: ( /j.gastro ) Copyright © 2018 AGA Institute Terms and Conditions
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