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Wai–Kit Lo, Walter W. Chan  Clinical Gastroenterology and Hepatology 

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Presentation on theme: "Wai–Kit Lo, Walter W. Chan  Clinical Gastroenterology and Hepatology "— Presentation transcript:

1 Proton Pump Inhibitor Use and the Risk of Small Intestinal Bacterial Overgrowth: A Meta-analysis 
Wai–Kit Lo, Walter W. Chan  Clinical Gastroenterology and Hepatology  Volume 11, Issue 5, Pages (May 2013) DOI: /j.cgh Copyright © 2013 AGA Institute Terms and Conditions

2 Figure 1 Flow diagram depicting the search and selection process.
Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

3 Figure 2 Meta-analysis of SIBO risk with PPI use.
Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

4 Figure 3 (A) One-study-removed analysis of SIBO risk to assess the single large study effect. (B) Cumulative analysis of SIBO risk to assess the consistency of results over time. (C) Funnel plot of standard error by SIBO risk. Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions

5 Figure 4 Subgroup analyses of SIBO risk with PPI use. (A) Subgroup analysis of SIBO risk with PPI use based on SIBO testing modality (duodenal/jejunal aspirate culture vs GHBT). (B) Subgroup analysis based on study design (pretest-posttest/self-control vs separate control). Clinical Gastroenterology and Hepatology  , DOI: ( /j.cgh ) Copyright © 2013 AGA Institute Terms and Conditions


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