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E. Munsterhjelm, T. T. Niemi, M. T. Syrjälä, O. Ylikorkala, P. H

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Presentation on theme: "E. Munsterhjelm, T. T. Niemi, M. T. Syrjälä, O. Ylikorkala, P. H"— Presentation transcript:

1 Propacetamol augments inhibition of platelet function by diclofenac in volunteers 
E. Munsterhjelm, T.T. Niemi, M.T. Syrjälä, O. Ylikorkala, P.H. Rosenberg  British Journal of Anaesthesia  Volume 91, Issue 3, Pages (September 2003) DOI: /bja/aeg195 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

2 Fig 1 Platelet aggregation induced with arachidonic acid. The box-plots show medians, 25th/75th and 5th/95th percentiles. Each volunteer (n=10) was given placebo, diclofenac (diclo.) and a combination of diclofenac and propacetamol (comb.). Statistical tests are: Friedman repeated measures analysis of variance on ranks test (all groups) and Wilcoxon signed rank test (diclo. vs comb.). *P<0.001, all groups; **P=0.014; ***P=0.50; †P=1.00. British Journal of Anaesthesia  , DOI: ( /bja/aeg195) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

3 Fig 2 Amount of pain induced with the cold pressor test after 30 s. The figure shows all individual estimations, before the infusion (pre) and at 5 and 90 min thereafter. Each volunteer (n=10) was given placebo, diclofenac and a combination of diclofenac and propacetamol. Statistics with the Friedman repeated measures analysis of variance on ranks test. *P=0.72, all groups; **P=0.71; ***P=0.38. British Journal of Anaesthesia  , DOI: ( /bja/aeg195) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions


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