1. Articular cartilage degeneration classification by means of high-frequency ultrasound 
N. Männicke, M. Schöne, M. Oelze, K. Raum 
Osteoarthritis and Cartilage 
Volume 22, Issue 10, Pages (October 2014)
DOI: /j.joca
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

2. Fig. 1
Class plots (left panels) with the best performing ultrasound-based parameter pairs and the corresponding ROC curves (right panels) for all six Mankin subset score classifications. The positive (red data points) and negative (blue) class labels represent lower and higher Mankin scores, respectively. Classification output is highlighted by circles in blue and red, the class boundaries are indicated by black dashed lines. The right panels display the ROC curves in blue. The curves with no predictive value are illustrated by dotted lines.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions

3. Fig. S1
Supplemental figure: Cross-sectional view of ultrasound measurements of (a) a healthy cartilage sample (Mankin surface structure score M1 = 0 and Mankin cell score M2 = 0) and (c) a sample with moderate signs of osteoarthrosis (M1 = 2 and M2 = 2). Cartilage surface, extracellular matrix and subchondral bone boundary are highlighted in the images. The gray cube illustrates the scaling of the volume and depicts an edge length of 1 mm. The bounding box is displayed in white, the locations of the cross-sections in orange color. Note the homogeneous strong backscatter amplitude (indicated by white arrows) in the tangential and transitional zones in the healthy cartilage sample, whereas backscatter appears more heterogeneous and extends to a larger depth in the moderately degenerated sample. Moreover, differences in surface reflection amplitude (brightness) and surface roughness can be seen (white asterisks). On the right hand side of the healthy cross sectional ultrasound image, a fissure can be observed that was created during biopsy extraction. Several areas with surface fibrillations are visible in the degenerated sample. Fly-through videos of the same measurements are provided in the supplementary material. The associated histology images of healthy and moderately degenerated cartilage samples are displayed in (b) and (d), respectively. The healthy sample exhibits a normal cartilage structure with a smooth intact surface (asterisk) and no cellular abnormalities (arrows). In the degenerated sample (d), a pannus (not shown) surface fibrillations (asterisks) and cell cloning (arrows) can be observed.
Osteoarthritis and Cartilage  , DOI: ( /j.joca )
Copyright © 2014 Osteoarthritis Research Society International Terms and Conditions