1. Berger JS, et al. JAMA 2009;301:

2. Flow Diagram of the Literature Search and Trial Selection Process
Berger JS, et al. JAMA 2009;301:

3. Design of Trials Included in the Meta-analysis - Part I
Berger JS, et al. JAMA 2009;301:

4. Design of Trials Included in the Meta-analysis - Part II
Berger JS, et al. JAMA 2009;301:

5. Effect of Any Aspirin on the Prevention of Composite Cardiovascular End Points
Berger JS, et al. JAMA 2009;301:

6. Effect of Any Aspirin on the Prevention of Nonfatal Myocardial Infarction, Nonfatal Stroke, and Cardiovascular Death
Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured.
a - Pooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval.
Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured.
aPooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval.
Berger JS, et al. JAMA 2009;301:

7. Effect of Any Aspirin on the Prevention of Any Death and Major Bleed
Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured.
aPooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval.
Berger JS, et al. JAMA 2009;301:

8. Effect of Aspirin Monotherapy on the Prevention of Adverse Outcomes
Major cardiovascular events defined as the composite of nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured.
a - Pooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval.
Major cardiovascular events defined as the composite of nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured.
aPooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval.
Berger JS, et al. JAMA 2009;301: