1. Extracellular mitochondria cause neutrophil recruitment.
Extracellular mitochondria cause neutrophil recruitment. (A) C57BL/6 mice received i.p. injections of mitochondria (300 mg) isolated from healthy, apoptotic, or necroptotic L929 cells (n = 6 per group), or with an equal volume of PBS (vehicle control; n = 6), or with zymosan (positive control; 100 mg; n = 2). PECs were harvested 18 h after injection, and neutrophils were enumerated based on FACS analysis for Ly6G+Ly6B.2+ cells. (B) PEC neutrophils were enumerated and compared. Comparisons were performed using a Kruskal–Wallis with Dunn multiple comparison test. A p value <0.05 was considered significant.
Minghua Zhu et al. ImmunoHorizons 2018;2:
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