1. A Bacterial Pathogen Flips the Riboswitch
Bobbi Xayarath, Nancy E. Freitag 
Cell Host & Microbe 
Volume 6, Issue 5, Pages (November 2009)
DOI: /j.chom
Copyright © 2009 Elsevier Inc. Terms and Conditions

2. Figure 1 Model of SreA cis and trans Regulation
(A) The SreA riboswitch is located immediately upstream of three genes, lmo In the absence of the metabolite SAM, SreA forms an antitermination structure that allows transcription of the downstream genes.
(B) Binding of SAM to SreA alters its formation and a terminator structure is formed, resulting in the production of a short transcript lacking the downstream genes. This small RNA is capable of binding the prfA mRNA at high temperature (37°C) leading to a reduction in PrfA protein synthesis. At low temperatures (≤30°C), the thermosensor element located in the 5′UTR of prfA mRNA prevents both SreA binding and prfA mRNA translation.
Cell Host & Microbe 2009 6, DOI: ( /j.chom )
Copyright © 2009 Elsevier Inc. Terms and Conditions