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Prognostic Value of Chromosomal Imbalances in Squamous Cell Carcinoma and Adenocarcinoma of the Lung  Bernhard C. Danner, MD, Timo Hellms, MD, Klaus Jung,

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Presentation on theme: "Prognostic Value of Chromosomal Imbalances in Squamous Cell Carcinoma and Adenocarcinoma of the Lung  Bernhard C. Danner, MD, Timo Hellms, MD, Klaus Jung,"— Presentation transcript:

1 Prognostic Value of Chromosomal Imbalances in Squamous Cell Carcinoma and Adenocarcinoma of the Lung 
Bernhard C. Danner, MD, Timo Hellms, MD, Klaus Jung, PhD, Bastian Gunawan, MD, PhD, Vassilios Didilis, MD, PhD, Laszlo Füzesi, MD, PhD, Friedrich A. Schöndube, MD, PhD  The Annals of Thoracic Surgery  Volume 92, Issue 3, Pages (September 2011) DOI: /j.athoracsur Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

2 Fig 1 Relative frequency of single chromosomal aberrations (gains and losses) in 55 squamous cell carcinoma (black bars) and 25 adenocarcinoma (white bars). Asterisk indicates significant difference of frequency between squamous cell carcinoma and adenocarcinoma. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

3 Fig 2 Oncogenetic tree models for chromosomal aberrations with frequency over 20% in squamous cell carcinoma (A) and adenocarcinoma (B). The final points give the chromosomal imbalances, detected by comparative genomic hybridization, whereas the inner branches mark invisible events. The closer the final points are on the left (root of the tree), the earlier the imbalances occur in genetic evolution. Interconnection of the paths indicates high correlation of events, forming a cluster of genetic imbalances. The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions

4 Fig 3 Cumulative overall survival for the different clusters in squamous cell carcinoma (SCC). The Annals of Thoracic Surgery  , DOI: ( /j.athoracsur ) Copyright © 2011 The Society of Thoracic Surgeons Terms and Conditions


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