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Genomics and the circulation
M.V. Podgoreanu, D.A. Schwinn British Journal of Anaesthesia Volume 93, Issue 1, Pages (July 2004) DOI: /bja/aeh168 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions
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Fig 1 Integrating cardiovascular ‘omic’ information. Cellular function is organized as a multilayered set of interdependent processes: genome (DNA), transcriptome (messenger RNA), proteome (the collection of all proteins encoded within the DNA of a genome), physiome (regulatory networks and signalling pathways), and phenome (the quantitative description of the integrated functions of the living organism, and its interactions both with the environment and within the phenotype itself). An integrative systems biology approach will provide a quantitative and mechanistic description that unifies signalling networks in cardiovascular disease and will identify critical regulatory nodes for therapeutic manipulation. British Journal of Anaesthesia , DOI: ( /bja/aeh168) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions
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