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Rene L. Begay et al. JACEP 2018;4:

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1 Rene L. Begay et al. JACEP 2018;4:504-514
Structural Distribution of Truncating Variants in the Human FLNC Protein Schematic of the FLNC immunoglobulin-like repeats labeled 1 to 24 using transcript NP_ Hinge 1 and 2 domains are labeled as H1 and H2, respectively. Red vertical lines indicate protein positions of the 6 FLNC truncation variants detected in our dilated cardiomyopathy (DCM) families. Black vertical lines represent previously reported hypertrophic cardiomyopathy (HCM) (7), restrictive cardiomyopathy (RCM) (8), DCM variants (12), and myofibrillar skeletal myopathies (MFM) (6) variants. Rene L. Begay et al. JACEP 2018;4: 2018 The Authors

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