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Volume 119, Issue 3, Pages (September 2000)

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Presentation on theme: "Volume 119, Issue 3, Pages (September 2000)"— Presentation transcript:

1 Volume 119, Issue 3, Pages 806-815 (September 2000)
Mechanism for the transit-induced increase in colonic deoxycholic acid formation in cholesterol cholelithiasis  Linzi A. Thomas, Martin J. Veysey, Tracy Bathgate, Anna King, Gary French, Nigel C. Smeeton, Gerard M. Murphy, R.Hermon Dowling  Gastroenterology  Volume 119, Issue 3, Pages (September 2000) DOI: /gast Copyright © 2000 American Gastroenterological Association Terms and Conditions

2 Fig. 1 LBTT in stone-free control subjects and patients with cholesterol GBS (including data points with means and SEMs). In the control group, the asterisks identify the 4 individuals with presumed slow-transit constipation. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

3 Fig. 2 (A) Total anaerobic bacterial counts and (B) Gram-positive anaerobic bacterial counts measured in colony-forming units per milliliter of cecal aspirate from stone-free control subjects and patients with cholesterol GBS. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

4 Fig. 3 7α-DH activity in stone-free controls and patients with cholesterol GBS. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

5 Fig. 4 (A) Proximal colonic pH and (B) distal colonic pH, using an expanded scale, from stone-free control subjects and patients with cholesterol GBS. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

6 Fig. 5 Proportion of DCA, expressed as a percentage of total serum bile acids, in stone-free control subjects and patients with cholesterol GBS. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions

7 Fig. 6 Relationship between serum total DCA (expressed as a percentage of serum total bile acids) and (A) LBTT and (B) distal colonic luminal pH. ○, Stone-free controls; ●, patients with cholesterol GBS. Gastroenterology  , DOI: ( /gast ) Copyright © 2000 American Gastroenterological Association Terms and Conditions


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