1. Role of arachidonic acid-derived metabolites in the control of pulmonary arterial pressure and hypoxic pulmonary vasoconstriction in rats 
S.J. Park, H.Y. Yoo, Y.E. Earm, S.J. Kim, J.K. Kim, S.D. Kim 
British Journal of Anaesthesia 
Volume 106, Issue 1, Pages (January 2011)
DOI: /bja/aeq268
Copyright © 2011 The Author(s) Terms and Conditions

2. Fig 1
Effects of blood on HPV in V/P lungs. Representative traces of PAP. Lungs were initially perfused with PSS only. Angiotensin II (1 µg) induced a transient increase in PAP. The closed bars indicate hypoxic ventilation (3% Po2). PSS-only perfusate was replaced by (a) blood- or (b) RBCs-containing PSS.
British Journal of Anaesthesia  , 31-37DOI: ( /bja/aeq268)
Copyright © 2011 The Author(s) Terms and Conditions

3. Fig 2
Effects of COX inhibitor on HPV in V/P lungs. Representative traces of PAP in the presence (a) or absence (b) of COX inhibitors. (c) ΔPAP values are shown as a box and whisker plot (median, IQR). Closed squares represent mean values. *P<0.05.
British Journal of Anaesthesia  , 31-37DOI: ( /bja/aeq268)
Copyright © 2011 The Author(s) Terms and Conditions

4. Fig 3
Roles of endogenous TXA2, LTD4, PGI2, and expoxyeicosanoids on HPV in V/P lungs. Without COX inhibitors, SQ (a), LY (b), MK-886 (c), tranylcypromine (d) and ODYA (e) were applied before the second hypoxic challenge (downward arrows). ΔPAP values are summarized in the right panels (median, IQR, a–e). Baseline PAP (BLPAP) normalized vs controls (mean and sd) are summarized in (f). Closed bar=control, green bars with left diagonal lines=maximum changes in BLPAP after drug treatment, pink bars with right diagonal lines=BLPAP after three hypoxic treatments. *P<0.05.
British Journal of Anaesthesia  , 31-37DOI: ( /bja/aeq268)
Copyright © 2011 The Author(s) Terms and Conditions

5. Fig 4
Effects of U46619, PGI2, or LTD4 on HPV in V/P lungs. (a) U46619 increased both PAP and ΔPAPhypox. (b) In contrast, PGI2 eliminated ΔPAPhypox and decreased basal PAP. (c) LTD4 did not alter HPV. ΔPAP values are summarized in the right panels (median, IQR, a–c). Closed square=mean value. In (d), normalized baseline PAP (BLPAP) values are summarized (mean and sd). Closed bar=control, green bars with left diagonal lines=maximum changes in BLPAP after drug treatment, pink bars with right diagonal lines=BLPAP after three hypoxic challenges. *P<0.05, **P<0.01.
British Journal of Anaesthesia  , 31-37DOI: ( /bja/aeq268)
Copyright © 2011 The Author(s) Terms and Conditions

6. Fig 5
Critical role of TXA2 for HPV in PAs. (a) Hypoxia (Po2, 3%) alone did not induce HPV. U46619 (10 nM) induced a slight increase in basal tone, and hypoxia (Po2, 3%) in the presence of U46619 induced a strong contraction. Angiotensin II (30 nM) induced a transient contraction, but additional hypoxia had no effect. (b) Indomethacin (10 µM) pretreatment did not affect HPV in the presence of U46619 (10 nM, left panel), whereas SQ (1 µM) completely blocked U46619 (50 nM)-induced contraction and HPV (right panel). In (c) and (d), summaries of PA tone normalized to 80 K+ contraction are shown in bar graphs (mean and sd). Indo, indomethacin; U, U46619; SQ, SQ
British Journal of Anaesthesia  , 31-37DOI: ( /bja/aeq268)
Copyright © 2011 The Author(s) Terms and Conditions