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Sevelamer Hydrochloride Binds Phosphate Released from Phytate in Chicks Fed 1α- Hydroxy Cholecalciferol Elizabeth A. Bobeck, BS, Katie M. Meyer, MS, Christian Helvig, PhD, Martin Petkovich, PhD, Mark E. Cook, PhD Journal of Renal Nutrition Volume 23, Issue 1, Pages (January 2013) DOI: /j.jrn Copyright © 2013 National Kidney Foundation, Inc. Terms and Conditions
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Figure 1 (A). Experiment 1 plasma phosphate (mg/dL) treatment averages shown with standard error bars (n ≥ 16). Chicks were fed a basal diet with and without sevelamer or 1α-(OH) D3 for 10 days, starting on day 3 of age, and phosphate was determined from plasma. abMeans with different letter superscripts are different, P < Interaction of sevelamer and 1α-(OH) D3 was significant (P < .002). (B). Experiment 2 plasma phosphate (mg/dL) treatment average shown with standard error bars (n ≥ 10). Chicks were fed a basal diet with or without sevelamer in the presence of added dietary inorganic phosphate or 1α-(OH) D3 for 10 days starting on day 0 and then plasma phosphate was determined. abcMeans with different letter superscripts are different, P < Main effects: D, P < .0001; Sev, P < .0025; interaction NS. Sev, sevelamer hydrochloride; D, 1α-(OH) D3, Pi, added inorganic phosphate balanced with calcium. Journal of Renal Nutrition , 21-27DOI: ( /j.jrn ) Copyright © 2013 National Kidney Foundation, Inc. Terms and Conditions
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