1. Volume 7, Issue 4, Pages 289-293 (March 2001)
Interleukin-4 reversed the Interleukin-1-inhibited proteoglycan synthesis through the inhibition of NO release: a possible involvement of intracellular calcium ion 
Fumiaki Nishisaka, Satoshi Sohen, Hiroshi Fukuoka, Yoshiyuki Okamoto, Masataka Matukawa, Kanji Fukuda, Chiaki Hamanishi 
Pathophysiology 
Volume 7, Issue 4, Pages (March 2001)
DOI: /S (00)

2. Fig. 1
Effect of IL-4 on IL-1-stimulated NO release. Chondrocytes from the superficial (○) and deep (•) layer were cultured for 24 h in the presence of IL-1 (1 ng/ml). Different concentrations of IL-4 were added simultaneously with IL-1. Data are expressed as a percentage of the control. The means of five wells are plotted. Circles and bars represent mean±S.D.
Pathophysiology 2001 7, DOI: ( /S (00) )

3. Fig. 2
Cytosolic calcium response. Chondrocytes obtained from the superficial (A) and deep (B) layers were preincubated in the absence (solid line) or presence (broken line) of IL-1Ra (1 ng/ml); then, media were changed to incubation medium to measure [Ca2+1i. Representative fluorescence emission tracings of [Ca2+]i in response to IL-1 (1 ng/ml, arrows) are shown. Data of one representative cell are expressed.
Pathophysiology 2001 7, DOI: ( /S (00) )

4. Fig. 3
Effect of IL-4 on the IL-1-stimulated increase in [Ca2+]i. Chondrocytes obtained from the superficial and deep layers were preincubated in the absence or presence of different concentrations of IL-4. The peak value of [Ca2+]i after IL-1 (1 ng/ml) is plotted. Data are expressed as the mean of 10 wells. Columns and bars represent mean±S.D. *P<0.05.
Pathophysiology 2001 7, DOI: ( /S (00) )