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Interleukin-6 participation in pathology of ocular diseases

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Presentation on theme: "Interleukin-6 participation in pathology of ocular diseases"— Presentation transcript:

1 Interleukin-6 participation in pathology of ocular diseases
Forouhe Zahir-Jouzdani, Fatemeh Atyabi, Nazanin Mojtabavi  Pathophysiology  Volume 24, Issue 3, Pages (September 2017) DOI: /j.pathophys Copyright © 2017 Elsevier B.V. Terms and Conditions

2 Fig. 1 IL6 cellular pathways, IL-6 induces homodimerization of gp130 then activates JAK family tyrosine kinases, JAKs induce tyrosine phosphorylation of gp130 and recruitment of STAT3 via the SH2 domain. Followed by phosphorylation of STAT3 by JAKs, it will translocate into the nucleus to regulate gene activation. Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2017 Elsevier B.V. Terms and Conditions

3 Fig 2 IL6 induces ocular neovascularization.
Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2017 Elsevier B.V. Terms and Conditions

4 Fig. 3 IL6 has roles in the pathogenesis of many ocular disease.
Pathophysiology  , DOI: ( /j.pathophys ) Copyright © 2017 Elsevier B.V. Terms and Conditions


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