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The COX-2 Specific Inhibitor, Valdecoxib, Is An Effective, Opioid-Sparing Analgesic in Patients Undergoing Total Knee Arthroplasty  Lowell W Reynolds,

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Presentation on theme: "The COX-2 Specific Inhibitor, Valdecoxib, Is An Effective, Opioid-Sparing Analgesic in Patients Undergoing Total Knee Arthroplasty  Lowell W Reynolds,"— Presentation transcript:

1 The COX-2 Specific Inhibitor, Valdecoxib, Is An Effective, Opioid-Sparing Analgesic in Patients Undergoing Total Knee Arthroplasty  Lowell W Reynolds, MD, Robert K Hoo, MD, Robert J Brill, MD, Janine North, MS, David P Recker, MD, Kenneth M Verburg, PhD  Journal of Pain and Symptom Management  Volume 25, Issue 2, Pages (February 2003) DOI: /S (02)

2 Fig. 1 Cumulative amount of morphine consumed over 48 hours (mean ± SEM: standard error of the mean). Patients receiving valdecoxib 40 mg bid consumed statistically significantly less morphine compared with those patients receiving morphine alone from 24 hours till the end of the study period *P < 0.05. Journal of Pain and Symptom Management  , DOI: ( /S (02) )

3 Fig. 2 Pain Intensity Difference Categorical Scale (Mean ± SEM) over 48 hours. Pain intensity at time specific intervals was lower in the valdecoxib 20 mg bid and valdecoxib 40 mg bid treatment groups compared with morphine plus placebo. These differences were significant from 12–48 hours for valdecoxib 40 mg bid and for valdecoxib 20 mg bid at 18, 24 and 36 hours *P < PID scores were derived by subtracting the pain intensity score at each time point from the baseline pain intensity score. A higher positive score indicates greater pain relief, whereas a negative score indicates increased pain intensity from baseline. Journal of Pain and Symptom Management  , DOI: ( /S (02) )

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