1. Prevalence and Mechanism of Nonsteroidal Anti-Inflammatory Drug–Induced Clinical Relapse in Patients With Inflammatory Bowel Disease 
Ken Takeuchi, Simon Smale, Purushothaman Premchand, Laurence Maiden, Roy Sherwood, Bjarni Thjodleifsson, Einar Bjornsson, Ingvar Bjarnason 
Clinical Gastroenterology and Hepatology 
Volume 4, Issue 2, Pages (February 2006)
DOI: /S (05)
Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions

2. Figure 1
The effect of acetaminophen, naproxen, nabumetone, nimesulide, and aspirin on clinical relapse and intestinal inflammation in patients with inflammatory bowel disease. Four patients each had a clinical relapse (identified by *) within a week of naproxen and nabumetone ingestion, which is significantly greater (P = .009) than the no relapses in patients taking acetaminophen at 1 week, and 1 patient each had a late relapse of disease on paracetamol and nimesulide. All of the clinical relapses were associated with increased calprotectin levels. Patients who discontinued the study prematurely (for various personal reasons) without an increase in clinical disease activity (identified by +) did not have increased fecal calprotectins.
Clinical Gastroenterology and Hepatology 2006 4, DOI: ( /S (05) )
Copyright © 2006 American Gastroenterological Association Institute Terms and Conditions