1. Immune response to vaccination with AVA in NZW rabbits (rabbit preexposure prophylaxis study).
Immune response to vaccination with AVA in NZW rabbits (rabbit preexposure prophylaxis study). Animals were immunized with serial dilutions of the human dose of AVA on days 0 and 28. Control animals were immunized with adjuvant alone (saline with 650 μg of aluminum hydroxide gel). On day 70, all rabbits were challenged via inhalation with 200 LD50 of aerosolized B. anthracis spores. Each TNA NF50 value was calculated as the ratio of the ED50 of the test sample to the ED50 of the reference standard. Individual values below the LOQ were replaced with the LOQ value (0.086) for statistical analysis purposes.
Boris Ionin et al. Clin. Vaccine Immunol. 2013; doi: /CVI