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Protective efficacy of prolonged co-trimoxazole prophylaxis in HIV-exposed children up to age 4 years for the prevention of malaria in Uganda: a randomised.

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Presentation on theme: "Protective efficacy of prolonged co-trimoxazole prophylaxis in HIV-exposed children up to age 4 years for the prevention of malaria in Uganda: a randomised."— Presentation transcript:

1 Protective efficacy of prolonged co-trimoxazole prophylaxis in HIV-exposed children up to age 4 years for the prevention of malaria in Uganda: a randomised controlled open- label trial  Dr Jaco Homsy, MD, Grant Dorsey, MD, Emmanuel Arinaitwe, MD, Humphrey Wanzira, MBChB, Abel Kakuru, MBChB, Victor Bigira, MBChB, Mary Muhindo, MBChB, Prof Moses R Kamya, MD, Taylor G Sandison, PhD, Jordan W Tappero, MD  The Lancet Global Health  Volume 2, Issue 12, Pages e727-e736 (December 2014) DOI: /S X(14) Copyright © 2014 Homsy et al. Open Access article distributed under the terms of CC BY Terms and Conditions

2 Figure 1 Study profile CTX=co-trimoxazole. *Results of the first randomisation have been previously reported.17 †Unrelated to CTX: this child had recurrent episodes of hemolytic anaemia after treatment with dihydroartemisinin-piperaquine that were later shown to be due to glucose-6-phosphate dehydrogenase deficiency. The Lancet Global Health 2014 2, e727-e736DOI: ( /S X(14) ) Copyright © 2014 Homsy et al. Open Access article distributed under the terms of CC BY Terms and Conditions

3 Figure 2 Malaria incidence in relation to age for all groups
CTX=co-trimoxazole. BF=breastfeeding. Full lines represent time when children were on CTX. Dotted lines represent time when children were not on CTX. The first randomisation of HIV-exposed children occurred at the end of breastfeeding, between 6 weeks and 9 months of age. The second randomisation of HIV-exposed children occurred at age 24 months. The Lancet Global Health 2014 2, e727-e736DOI: ( /S X(14) ) Copyright © 2014 Homsy et al. Open Access article distributed under the terms of CC BY Terms and Conditions


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