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A Molecular Link Tethering Neuronal Responses with the Past

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Presentation on theme: "A Molecular Link Tethering Neuronal Responses with the Past"— Presentation transcript:

1 A Molecular Link Tethering Neuronal Responses with the Past
Luca Della Santina, Rachel O.L. Wong  Cell  Volume 151, Issue 1, Pages 9-11 (September 2012) DOI: /j.cell Copyright © 2012 Elsevier Inc. Terms and Conditions

2 Figure 1 Adjusting Structure and Function According to Prior Experience Patterned visual stimuli evoke calcium responses that are correlated with dendritic dynamics in developing Xenopus tectal neurons. A full-field training stimulus induces long-term potentiation (LTP) in the neurons. This is accompanied by the stabilization of dendritic filopodia that are generated prior to experiencing the training stimulus (pre-training). A white noise, unpatterned stimulus, presented before the same training stimulus results in depression instead of potentiation, as well as destabilization of filopodia. This metaplasticity involves activation of NMDA receptors, followed by a cascade of intracellular events leading to altered transcription of genes related to synaptic plasticity. Cell  , 9-11DOI: ( /j.cell ) Copyright © 2012 Elsevier Inc. Terms and Conditions

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