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Low Risk of Chronic Graft-versus-Host Disease and Relapse Associated with T Cell– Depleted Peripheral Blood Stem Cell Transplantation for Acute Myelogenous.

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Presentation on theme: "Low Risk of Chronic Graft-versus-Host Disease and Relapse Associated with T Cell– Depleted Peripheral Blood Stem Cell Transplantation for Acute Myelogenous."— Presentation transcript:

1 Low Risk of Chronic Graft-versus-Host Disease and Relapse Associated with T Cell– Depleted Peripheral Blood Stem Cell Transplantation for Acute Myelogenous Leukemia in First Remission: Results of the Blood and Marrow Transplant Clinical Trials Network Protocol 0303  Steven M. Devine, Shelly Carter, Robert J. Soiffer, Marcelo C. Pasquini, Parameswaran N. Hari, Anthony Stein, Hillard M. Lazarus, Charles Linker, Edward A. Stadtmauer, Edwin P. Alyea, Carolyn A. Keever-Taylor, Richard J. O’Reilly  Biology of Blood and Marrow Transplantation  Volume 17, Issue 9, Pages (September 2011) DOI: /j.bbmt Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

2 Figure 1 Recovery of lymphocytes by day posttransplantation. Values are expressed as median ± standard error. Shaded areas represent the 25th-75th percentile range for normal individuals. (A) CD4+ cells. (B) CD8+ cells. (C) NK cells (CD56+ cells). (D) B cells. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

3 Figure 2 Cumulative incidence of grade II-IV acute GVHD (A), grade III-IV acute GVHD (B), and extensive/limited chronic GVHD (C). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

4 Figure 3 Cumulative incidence of relapse for all transplant recipients. Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

5 Figure 4 Kaplan-Meier estimates of DFS for all transplant recipients (A), DFS by remission state (B), OS for all transplant recipients (C), and OS by remission state (D). Biology of Blood and Marrow Transplantation  , DOI: ( /j.bbmt ) Copyright © 2011 American Society for Blood and Marrow Transplantation Terms and Conditions

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