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A Pharmacokinetic and Tolerability Evaluation of Two Continuous Subcutaneous Infusion Systems Compared to an Oral Controlled-Release Morphine  Pia Mikkelsen.

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Presentation on theme: "A Pharmacokinetic and Tolerability Evaluation of Two Continuous Subcutaneous Infusion Systems Compared to an Oral Controlled-Release Morphine  Pia Mikkelsen."— Presentation transcript:

1 A Pharmacokinetic and Tolerability Evaluation of Two Continuous Subcutaneous Infusion Systems Compared to an Oral Controlled-Release Morphine  Pia Mikkelsen Lynch, MD, Jackie Butler, PhD, Deanne Huerta, LVN, Izrail Tsals, PhD, Diana Davidson, BS, Sharon Hamm, PharmD, RPh  Journal of Pain and Symptom Management  Volume 19, Issue 5, Pages (May 2000) DOI: /S (00)

2 Fig. 1 MEDIPAD drug delivery system
Journal of Pain and Symptom Management  , DOI: ( /S (00) )

3 Fig. 2 Top: Mean morphine plasma concentration versus time for MEDIPAD vs. CADD-Micro. Bottom: Mean morphine plasma concentration versus time for MS Contin Journal of Pain and Symptom Management  , DOI: ( /S (00) )

4 Fig. 2 Top: Mean morphine plasma concentration versus time for MEDIPAD vs. CADD-Micro. Bottom: Mean morphine plasma concentration versus time for MS Contin Journal of Pain and Symptom Management  , DOI: ( /S (00) )

5 Fig. 3 Top: Mean morphine plasma concentration versus time showing standard error for the MEDIPAD and the CADD-Micro. Bottom: Mean morphine plasma concentration versus time showing standard error for MS Contin Journal of Pain and Symptom Management  , DOI: ( /S (00) )

6 Fig. 3 Top: Mean morphine plasma concentration versus time showing standard error for the MEDIPAD and the CADD-Micro. Bottom: Mean morphine plasma concentration versus time showing standard error for MS Contin Journal of Pain and Symptom Management  , DOI: ( /S (00) )

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