Presentation is loading. Please wait.

Presentation is loading. Please wait.

Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national.

Similar presentations


Presentation on theme: "Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national."— Presentation transcript:

1 Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15  Brian Wahl, PhD, Prof Katherine L O'Brien, MD, Adena Greenbaum, MD, Anwesha Majumder, MHS, Li Liu, PhD, Yue Chu, MSPH, Ivana Lukšić, MD, Prof Harish Nair, PhD, David A McAllister, MD, Prof Harry Campbell, MD, Prof Igor Rudan, MD, Prof Robert Black, MD, Maria Deloria Knoll, PhD  The Lancet Global Health  Volume 6, Issue 7, Pages e744-e757 (July 2018) DOI: /S X(18)30247-X Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

2 Figure 1 Pathogen-specific pneumonia, meningitis, and NPNM morbidity and mortality conceptual models MCEE=Maternal and Child Epidemiology Estimation. NPNM=non-pneumonia, non-meningitis. CFR=case–fatality ratio. *See Methods for description of vaccine adjustments. †Pneumococcal NPNM cases are stratified by severe and non-severe cases. ‡We assumed non-severe pneumococcal NPNM cases to have a 0% CFR; all pneumococcal NPNM deaths are assumed to be severe. The Lancet Global Health 2018 6, e744-e757DOI: ( /S X(18)30247-X) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

3 Figure 2 Deaths due to pneumococcus and Hib in children aged 1–59 months Pneumococcal and Hib deaths in children aged 1–59 months from 2000 to 2015 are HIV-negative deaths only. WHO/UNICEF vaccine coverage estimates have been adjusted to represent the proportion of children aged 1–59 months that received PCV and Hib vaccine. Vertical bars denote uncertainty intervals. Pneumococcus=Streptococcus pneumoniae. Hib=Haemophilus influenzae type b. The Lancet Global Health 2018 6, e744-e757DOI: ( /S X(18)30247-X) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

4 Figure 3 Country-specific mortality rates and deaths attributable to pneumococcus in 2015 Mortality rates and deaths in children aged 1–59 months are HIV-negative deaths only. Mortality rates are deaths per 100 000 children aged 1–59 months. Pneumococcus=Streptococcus pneumoniae. The Lancet Global Health 2018 6, e744-e757DOI: ( /S X(18)30247-X) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

5 Figure 4 Country-specific mortality rates and deaths attributable to Hib in 2015 Mortality rates and deaths in children aged 1–59 months are HIV-negative deaths only. Mortality rates are deaths per 100 000 children aged 1–59 months. Hib=Haemophilus influenzae type b. The Lancet Global Health 2018 6, e744-e757DOI: ( /S X(18)30247-X) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions


Download ppt "Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national."

Similar presentations


Ads by Google