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Published byKatriina Niemelä Modified over 5 years ago
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Induction of endometrial plasminogen activator–inhibitor 1: a possible mechanism contributing to the effect of intrauterine levonorgestrel in the treatment of menorrhagia Eeva-Marja Rutanen, M.D., Ph.D., Ritva Hurskainen, M.D., Patrik Finne, M.D., Kristiina Nokelainen Fertility and Sterility Volume 73, Issue 5, Pages (May 2000) DOI: /S (00)
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Figure 1 Representative Northern blot analysis of tissue-type plasminogen activator (t-PA) mRNA and plasminogen activator inhibitor 1 (PAI-1) mRNA in the human endometrium. Total RNA was extracted from endometrial tissue samples obtained from women with and without objective menorrhagia. Samples were collected before any treatment and 6 months after insertion of a levonorgestrel-releasing intrauterine system (LNG–IUS). The phase of the menstrual cycle is indicated above each lane. P, proliferative; S, secretory; M, menstrual; L, LNG–IUS endometrium. The P and S lanes before L lanes come from the same women before the LNG–IUS was inserted. A human 28S rRNA probe was used to normalize the amount of RNA loaded in each lane. Rutanen. Intrauterine levonorgestrel system. Fertil Steril 2000. Fertility and Sterility , DOI: ( /S (00) )
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